摘要
报告1例泛发性急性皮肤型红斑狼疮.患者男,75岁,因双耳及面部出现红斑1月余来我院就诊.皮肤科检查:双侧面部、双耳可见融合性红斑,背部可见多发大小不等红斑、斑疹及红色丘疹,部分皮损基础上伴鳞屑.皮肤镜检查:镜下呈红色背景,毛囊口周围可见白晕,可见白色条状无结构区及黄白色鳞屑.面部皮损组织病理检查:表皮萎缩变薄,部分视野可见基底细胞液化变性,真皮浅中层血管周围淋巴细胞灶状浸润.阿辛蓝染色:真皮内灶状阳性.诊断:泛发性急性皮肤型红斑狼疮.予以口服羟氯喹联合甲泼尼龙片等治疗后,皮损基本消退,仅背部遗留色沉.随访至今无复发.
Abstract
A case of acute cutaneous lupus erythematosus is reported.A 75-year-old male presented with asymptomatic erythema on both the ears and face for over a month.Dermatological examination showed fused erythema on both sides of the face and ears.Multiple erythema,macu-lae and red papules in different sizes were seen on the back,and some lesions were accompanied with scales.Under a dermoscope,there were perifollicular white halos and amorphous areas with scales on red background.Histopathological examination of facial skin lesions showed epidermal atrophy and liquefaction degeneration of the basal cells,and perivascular infiltration of lympho-cytes in the superficial and middle dermis.Alcian blue staining was focally positive in the dermis.Diagnosis:generalized acute cutaneous lupus erythematosus.Satisfactory results were achieved af-ter oral administration of hydroxychloroquine combined with methylprednisolone tablets.No recur-rence was observed during follow-up.
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