The role of interaction between keratinocytes and type 2 inflammation in the pathogenesis of atopic dermatitis
Patients with atopic dermatitis(AD)have skin barrier dysfunction,which is closely related to keratinocyte(KC)abnormalities.Upon stimulation by external factors,KCs release a large number of inflammatory mediators,thereby activating type 2 inflammation,which,in turn,exacerbates skin barrier dysfunction.Thus,the interaction between KCs and type 2 inflammation is a key factor in the pathogenesis of AD,and exacerbation of inflammation and pruritus.At pres-ent,the innovative medications,such as biologies and small molecule drugs,have been shown an-ti-inflammatory effects in AD.Studies also demonstrate their role in skin barrier repair.Therefore,research on the interaction between KCs and type 2 inflammation will help understand the patho-genesis of AD and provide evidence to optimize treatment strategies for AD.
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