摘要
肥胖是世界范围内的一个重大公共卫生问题,与慢性炎症及其相关并发症发展密切相关,如银屑病、2型糖尿病、高脂血症、动脉粥样硬化等.肥胖和银屑病可能受饮食习惯、免疫、微生物群以及环境等多因素影响,但具体机制尚未完全明了.肥胖与银屑病的发展密切相关,主要是因为肥胖与银屑病患者的脂肪因子会使促炎因子活化从而加重银屑病症状.肥胖是银屑病患者的重要危险因素之一.与正常体质量人群相比,超重或肥胖会加重银屑病患者病情.本文从流行病学、人体测量指标、微生物群、饮食、促炎因子、治疗等多角度综述肥胖与银屑病之间可能存在的联系.
Abstract
Obesity is a major public health problem worldwide,which is linked to the develop-ment of chronic inflammation and its related complications,such as psoriasis,type 2 diabetes,hy-perlipidemia,atherosclerosis,etc.Obesity and psoriasis can be influenced by multiple factors,such as dietary habits,immune factors,microbiota and environmental factors,but the specific mechanisms are not yet clear.The link between obesity and psoriasis is mainly mediated by fat factors in obese and psoriatic patients,which can activate pro-inflammatory factors,thereby exac-erbating psoriasis symptoms.Obesity is one of the important risk factors for psoriatic patients.And compared to normal weight individuals,overweight or obesity can worsen psoriasis.This paper re-views the possible connections between obesity and psoriasis from multiple aspects,including epi-demiology,anthropometric indicators,microbiota,diet,pro-inflammatory factors and treatment.
基金项目
国家自然科学基金(82171583)
深圳市基础研究重点项目(JCYJ20200109150717745)
国家科技期刊平台
NSTL
维普
万方数据