沙眼衣原体外膜复合物蛋白B的研究进展
Research advances on Chlamydia trachomatis outer membrane complex protein B
孙悠娴 1齐蔓莉2
作者信息
- 1. 天津医科大学总医院,天津 300052
- 2. 天津市人民医院,天津 300000
- 折叠
摘要
沙眼衣原体(CT)是最常见的引起性传播疾病的病原体,由于其症状的隐匿性,感染者往往无法在疾病早期得到诊疗,最终导致疾病慢性迁延,出现一系列严重的并发症和后遗症.沙眼衣原体外膜复合物蛋白B(OmcB)是衣原体中含量第二丰富的多功能外膜蛋白.OmcB在衣原体内丰富的含量以及在衣原体感染过程中表现出的强大的免疫原性,使其在帮助CT感染的诊断以及疫苗研发方面具有很好的应用前景.本文对OmcB的结构、定位及CT感染过程中的相关机理进行综述.
Abstract
Chlamydia trachomatis is the most common sexually transmitted pathogen.Due to the latency of the symptoms,Chlamydia trachomatis cannot be diagnosed and treated in the early stage,leading to the development of severe chronic disease with complications and sequelae.Out-er membrane complex protein B(OmcB)is the second most abundant outer membrane protein in chlamydia.Because of its abundance and powerful immunogenicity during the infection,OmcB has a very promising prospect in the fields of the diagnosis of CT infection and the development of vaccines.This article reviews the structure and localization of OmcB,and the related mechanisms during Chlamydia trachomatis infection.
关键词
沙眼衣原体/外膜复合物蛋白B/免疫优势蛋白Key words
Chlamydia trachomatis/OmcB/immunodominant protein引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据