A case of Cronkhite-Canada syndrome is reported.A 68-year-old man presented with stomachache and diarrhea for 3 months.The dermatological examination revealed diffuse hair thinning,especially on the frontal region,symmetrical distribution of brown pigmentation covered with green bean-sized maculopapules on the upper and lower lips,hands,and soles.Two-thirds of distal part of the toenails were missing,with rough and uneven dull surface.Pitted edema was ob-served on the upper eyelids and legs.Laboratory examination showed anemia and hypoproteine-mia.Electronic colonoscopy revealed multiple polyps in the colon.Diagnosis:Cronkhite-Canada syndrome.Following high protein nutritional support and symptomatic treatment,anemia and hy-poproteinemia were significantly improved.The patient is still under follow-up.
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