马拉色菌外泌蛋白酶研究进展
Research progress on secreted proteases of Malassezia
谈桂其 1谭冬芳 1梁晓冬 1李慧慧 1邓新华1
作者信息
- 1. 暨南大学附属顺德医院,广东 佛山 528300
- 折叠
摘要
马拉色菌是皮肤常驻菌群,在一定条件下可致病,该菌致病机制参与因素繁多且复杂,其中外泌蛋白酶是关键因素之一.外泌蛋白酶是一种能够水解蛋白质肽键的酶,在富含蛋白质和脂质的皮肤环境中具有特殊的意义.目前有糠秕马拉色菌、球形马拉色菌、厚皮马拉色菌及限制性马拉色菌外泌蛋白酶等的相关研究,包括蛋白酶的发现及命名、蛋白酶活性、致病性.本文主要对糠秕马拉色菌、球形马拉色菌、厚皮马拉色菌及限制性马拉色菌外泌蛋白酶的研究进行综述.
Abstract
Malassezia is a group of resident fungi on the skin,which can cause diseases under certain conditions.Among the multiple complicated factors involved in the pathogenesis,secreted proteases of Malassezia are the key factors.Secreted proteases are enzymes capable of hydrolyzing protein peptide bonds,which has special significance in the skin environment enriched in proteins and lipids.So far,21 species of Malassezia have been identified.Most studies are related to iden-tification and naming,protease activity and pathogenicity of secreted proteases secreted by Malas-sezia furfur,Malassezia globosa,Malassezia pachydermatis and Malassezia restricta.This paper aims to review the research progress on the secreted proteases of Malassezia furfur,Malassezia glo-bose,Malassezia pachydermatis and Malassezia restricta.
关键词
马拉色菌/糠秕马拉色菌/球形马拉色菌/厚皮马拉色菌/外泌蛋白酶Key words
Malassezia/Malassezia furfur/Malassezia globose/Malassezia pachyderma-tis/secreted protease引用本文复制引用
基金项目
佛山市卫生健康局医学科研项目(20220307)
出版年
2024
国家科技期刊平台
NSTL
万方数据