Treatment of generalized pustular psoriasis with Spesolimab:a case report and literature review
Objective To evaluate the efficacy and safety of Spesolimab in the treatment of generalized pustular psoriasis(GPP).Methods A 30 years old female with GPP was intrave-nously given 900 mg of Spesolimab once.The safety and the changes in modified generalized pus-tular psoriasis area severity index(GPPASI)and generalized pustular psoriasis physician global assessment(GPPGA)were evaluated.Results After 1 week of the treatment,the GPPGA reached 2.After 2 months of the treatment,pustules almost completely subsided and both GPPASI and GPPGA reached 1.During the treatment,the patient developed anaphylactic adverse reac-tions,which were improved following the injection of betamethasone,antihistamine and symptom-atic therapy.Conclusion Spesolimab is an effective and safe agent for the treatment of general-ized pustular psoriasis.
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