首页|2018-2022年438株淋球菌临床分离株耐药性分析

2018-2022年438株淋球菌临床分离株耐药性分析

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目的 总结青霉素、四环素、环丙沙星、头孢克肟、头孢曲松、大观霉素和阿奇霉素等7种抗生素的耐药性监测结果,分析番禺区淋球菌耐药株的流行状况.方法 2018-2022年间收集番禺区性病门诊患者尿道或宫颈、阴道等泌尿生殖道分泌物中分离得到的淋球菌菌株,采用琼脂稀释法测定菌株对7种抗生素的最小抑菌浓度(MIC),用纸片酸度法检测产青霉素酶淋球菌(PPNG),比较各年度的淋球菌菌株对抗生素敏感性和流行率.结果 共收集并检测了 438株淋球菌,其中PPNG和四环素高水平耐药淋球菌(TRNG)流行率分别为48.86%和38.13%.四环素、环丙沙星、阿奇霉素的总耐药率分别为90.18%、96.12%和13.47%,青霉素的耐药率从2018年的50.60%升高至2022年的84.00%,差异有统计学意义(x2=23.59,P<0.01),未发现大观霉素、头孢曲松和头孢克肟耐药菌株.但头孢曲松和头孢克肟中敏菌株分别由2018年的2.41%(2/83)和3.61%(3/83)上升至2022年的13.00%(13/100)和25.00%(25/100),差异均有统计学意义(x2值分别为6.76、14.39,均P<0.01),呈动态升高趋势.结论 2018-2022年番禺区淋球菌菌株对大观霉素、头孢曲松和头孢克肟均敏感,头孢曲松和头孢克肟中度敏感率呈逐年升高态势,PPNG和TRNG也呈高度流行状态.
Analysis of antibiotic resistance of 438 clinical isolates of Neisseria gonorrhoeae obtained from 2018 to 2022
Objective To summarize the surveillance results of antibiotic resistance of Neisse-ria gonorrhoeae to 7 antibiotics(penicillin G,tetracycline,ciprofloxacin,spectinomycin,ce-fixime,ceftriaxone and Azithromycin)in Panyu District,Guangzhou,from 2018 to 2022.Meth-ods Neisseria gonorrhoeae strains were isolated from urogenital secretions such as urethra or cer-vical vagina at the sexually transmitted disease outpatient clinic of Panyu District from 2018 to 2022.The agar dilution method was used to determine the minimum inhibitory concentrations(MICs)of the seven antibiotics.Penicillinase-producing N.gonorrhoeae(PPNG)was analyzed by the paper acidometric method.The sensitivity and prevalence of Neisseria gonorrhoeae strains to antibiotics were compared among those years.Results A total of 438 strains of Neisseria gonor-rhoeae were collected.Among them,the rates of PPNG and TRNG were 48.86%(214/438)and 38.13%(167/438),respectively.The overall resistance rates to tetracycline,ciprofloxacin,and azithromycin were 90.18%,96.12%,and 13.47%,respectively.The resistance rate to penicil-lin was increased significantly from 50.60%in 2018 to 84.00%in 2022(x2=23.59,P<0.01).We found no strains resistant to spectinomycin,ceftriaxone,and cefixime.However,the intermediate sensitivity to ceftriaxone and cefixime was increased from 2.41%(2/83)and 3.61%(3/83)in 2018 to 13.00%(13/100)and 25.00%(25/100)respectively,in 2022(x2=6.76,P<0.01 and x2=14.39,P<0.01).Conclusions All Neisseria gonorrhoeae strains collected from 2018 to 2022 are sensitive to erythromycin,ceftriaxone,and cefixime.How-ever,there is a trend of yearly increase in the rates of low-sensitivity to ceftriaxone and cefixime,and PPNG and TRNG are also highly prevalent.

gonorrheaNeisseria gonorrhoeaedrug survellancemicrobial sensitivity testsdrug resistance analysis

梁焕喜、劳丽嫦、黎敬忠、何晓能、黄蕴怡、郭键瑜、郭炽星

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广州市番禺区慢性病防治站

广州市番禺区中心血站

广州市番禺区健康管理中心 广州市番禺区康复医院,广东 广州 511400

淋病 奈瑟氏球菌 药物监测 微生物敏感性试验 耐药性分析

番禺区科技计划项目

2021-Z04-107

2024

皮肤性病诊疗学杂志
广东省皮肤性病防治中心

皮肤性病诊疗学杂志

影响因子:0.666
ISSN:1674-8468
年,卷(期):2024.31(7)