Analysis of antibiotic resistance of 438 clinical isolates of Neisseria gonorrhoeae obtained from 2018 to 2022
Objective To summarize the surveillance results of antibiotic resistance of Neisse-ria gonorrhoeae to 7 antibiotics(penicillin G,tetracycline,ciprofloxacin,spectinomycin,ce-fixime,ceftriaxone and Azithromycin)in Panyu District,Guangzhou,from 2018 to 2022.Meth-ods Neisseria gonorrhoeae strains were isolated from urogenital secretions such as urethra or cer-vical vagina at the sexually transmitted disease outpatient clinic of Panyu District from 2018 to 2022.The agar dilution method was used to determine the minimum inhibitory concentrations(MICs)of the seven antibiotics.Penicillinase-producing N.gonorrhoeae(PPNG)was analyzed by the paper acidometric method.The sensitivity and prevalence of Neisseria gonorrhoeae strains to antibiotics were compared among those years.Results A total of 438 strains of Neisseria gonor-rhoeae were collected.Among them,the rates of PPNG and TRNG were 48.86%(214/438)and 38.13%(167/438),respectively.The overall resistance rates to tetracycline,ciprofloxacin,and azithromycin were 90.18%,96.12%,and 13.47%,respectively.The resistance rate to penicil-lin was increased significantly from 50.60%in 2018 to 84.00%in 2022(x2=23.59,P<0.01).We found no strains resistant to spectinomycin,ceftriaxone,and cefixime.However,the intermediate sensitivity to ceftriaxone and cefixime was increased from 2.41%(2/83)and 3.61%(3/83)in 2018 to 13.00%(13/100)and 25.00%(25/100)respectively,in 2022(x2=6.76,P<0.01 and x2=14.39,P<0.01).Conclusions All Neisseria gonorrhoeae strains collected from 2018 to 2022 are sensitive to erythromycin,ceftriaxone,and cefixime.How-ever,there is a trend of yearly increase in the rates of low-sensitivity to ceftriaxone and cefixime,and PPNG and TRNG are also highly prevalent.