摘要
皮肤是人体面对外部损伤的第一道屏障,日光中的紫外线可直接作用于皮肤表面对内环境产生影响,而体内激素水平的不同也可使机体对于紫外线照射的反应不同.紫外线可通过调节局部糖皮质激素水平抑制炎症,在不同性激素水平的影响下发挥不同的免疫抑制作用,参与调控胰岛素相关的糖代谢和脂质代谢的过程,而褪黑素则可以抑制紫外线的光老化作用.本文就紫外线与皮质醇激素、性激素、胰岛素及褪黑素间的关系进行阐述,为疾病的防治提供更多的可能性.
Abstract
The skin serves as the body's primary defense against external insults.Ultraviolet lights from the sun can directly impact the skin surface,affecting internal environment.At the same time,the body's response to ultraviolet lights varies with hormone levels.Under different levels of sex hormone,ultraviolet l ight can modulate local glucocorticoid levels,resulting in inhibi-tion of inflammation,immunosuppression,and regulation of insulin-related glucose and lipid me-tabolism.In contrast,melatonin can inhibit ultraviolet irradiation-induced skin aging.This article explores the links between ultraviolet irradiation and corticoids,sex hormones,insulin,and me-latonin,facilitating the development of approaches for the prevention and treatment of diseases.
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