炎症性肠病伴皮肤表现的临床与病理分析
Clinical and pathological analyses of two cases of inflammatory bowel disease with cutane-ous manifestations
丘晓英 1夏传刚 2肖文 2陈方如1
作者信息
- 1. 桂林医学院附属医院,广西 桂林 541001
- 2. 柳州市工人医院,广西 柳州 545005
- 折叠
摘要
目的 分析炎症性肠病(IBD)皮肤表现的临床及组织病理特点,为临床诊断提供指导.方法 回顾性分析2例IBD伴皮肤表现的临床及病理特点.结果 1例患者为克罗恩病合并皮肤表现,皮损表现为肛周红斑、溃疡,组织病理表现为真皮非干酪样非感染性肉芽肿,使用乌司奴单抗治疗后溃疡面积缩小.另1例为溃疡性结肠炎合并肠外表现,皮损表现为全身红斑、结节,小腿、臀部可见溃疡,组织病理表现为真皮中性粒细胞浸润,使用英夫利昔单抗治疗后皮损部分消退.结论 IBD合并皮肤表现具有不同的组织病理学特点.诊断时临床医生需结合临床表现及组织病理以免误诊漏诊.
Abstract
Objective To analyze the clinical and histopathological features of skin manifesta-tions of inflammatory bowel disease(IBD)in order to provide guidance for clinical diagnosis.Meth-ods Clinical and pathological characteristics of 2 patients with IBD were retrospectively analyzed.Results One patient had Crohn's disease manifested by perianal erythema and ulcers,and histopa-thology showed non-caseous and non-infectious granuloma in the dermis.Treatment with Ustekinum-ab decreased the ulcerative area.In another case of ulcerative colitis with extraintestinal manifesta-tions,erythemas and nodules were all over the body,and ulcers were on the lower legs and but-tocks.Histopathology showed dermal neutrophil infiltration.The skin lesions partially subsided after the treatment with Infliximab.Conclusions IBD with cutaneous manifestations has different his-topathological characteristics,and clinicians should make the diagnosis based on both clinical mani-festations and histopathological features in order to avoid misdiagnosis and missed diagnosis.
关键词
炎症性肠病/克罗恩病/溃疡性结肠炎/皮肤表现/病理特点Key words
inflammatory bowel disease/Crohn's disease/ulcerative colitis/skin mani-festations/pathological features引用本文复制引用
基金项目
桂林市卫生健康委医美康养人才小高地建设项目()
柳州市科技计划项目(2022CAC0227)
广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20170846)
出版年
2024
国家科技期刊平台
NSTL
万方数据