摘要
皮脂腺衰老通常始于曝光区域,表现为皮脂腺增生和脂质失调,进而导致皮肤干燥、缺乏光泽,促进菌群改变、色素沉着及皮肤疾病发生.在内源性及外源性因素作用下,皮脂腺导管发生扩张、脂质分泌减少、腺体增生并产生炎性浸润.介导皮脂腺衰老的下游机制包括ROS、自噬、Wnt信号通路、线粒体功能不良等.抗氧化、益生菌、光电疗法、外泌体对延缓皮脂腺衰老具有积极意义.本文从皮脂腺衰老的表现出发,阐述其内在的发生机制研究进展及应对措施.
Abstract
Aging in the sebaceous glands typically begins on the sun-exposed areas,character-ized by sebaceous gland hyperplasia and lipid dysbiosis.These changes result in dry and dull skin,alterations in the microbiota,pigmentation,and various skin diseases.Both intrinsic and ex-trinsic factors contribute to this process,causing dilation of sebaceous ducts,reducing lipid secre-tion,promoting gland proliferation,and inducing inflammation.Key downstream mechanisms driv-ing sebaceous gland aging include reactive oxygen species(ROS),autophagy,the Wnt signaling pathway,and mitochondrial dysfunction.Interventions such as antioxidants,probiotics,photother-apy,and exosomes can delay the sebaceous gland aging.This article will discuss the manifesta-tions of the sebaceous gland aging,elucidate its underlying mechanisms,review current research progress,and explore potential countermeasures.
国家科技期刊平台
NSTL
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