首页|基于生物信息学探讨银屑病合并肥胖的潜在机制及中药预测

基于生物信息学探讨银屑病合并肥胖的潜在机制及中药预测

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目的 通过生物信息学方法探索银屑病合并肥胖状态的核心靶点、重要通路以及潜在治疗中药.方法 利用OMIM、GeneCards、DisGeNET、TTD数据库查找银屑病与肥胖两病的共同作用靶点,通过Cytoscape鉴定核心共同靶点.对核心靶点进行GO及KEGG分析以阐明相关生物学过程.最终通过Coremine Medical数据库预测对核心靶点具有调控作用的相关中药.结果 银屑病合并肥胖的交集核心靶点基因共 13 个(IL-6、STAT3、TNF、IL-1B、IL-10、IFNG、CCL2、ICAM1、TLR4、TP53、CRP、PPARG、TYK2).富集显示上述靶点主要生物学过程涉及STAT受体信号通路和IL-8合成及调节等方面.KEGG分析显示主要涉及炎症性肠病及脂质和动脉粥样硬化通路.中药预测结果显示姜黄、人参、丹参、厚朴花、灵芝、黄连等多味中药具有潜在疗效.这些中药主要归脾胃经、肺经等,多行活血化瘀、补气、祛湿等功效.结论 银屑病与肥胖发病共有13个共同核心靶点,其发病与机体持续性炎症及血管改变相关.预测的中药为银屑病合并肥胖的治疗提供了依据.
Bioinformatics-based exploration of potential mechanisms and prediction of herbal medi-cines for psoriasis-associated obesity
Objective Using bioinformatics methods to explore the core targets and important pathways in and potential therapeutic herbs for psoriasis-associated obesity.Methods OMIM,GeneCards,DisGeNET,and TTD databases were used to identify the common targets of the two diseases,and the core common targets were identified by Cytoscape.The core targets were ana-lyzed by GO and KEGG to elucidate the related biological processes.Finally,the Coremine Medi-cal database was used to predict the related Chinese medicines that regulate the core targets.Results A total of 13 core targets(IL-6,STAT3,TNF,IL-1B,IL-10,IFNG,CCL2,ICAM1,TLR4,TP53,CRP,PPARG,TYK2)were identified as intersecting core targets in obesity associ-ated with psoriasis.Enrichment analysis showed that the main biological processes of these targets were involved the STAT receptor signaling pathway and IL-8 synthesis and regulation,etc.KEGG analysis showed that these genes were mainly involved in inflammatory bowel disease and pathways linked to lipid and atherosclerosis.The prediction results showed that multiple traditional Chinese medicines such as turmeric,ginseng,salvia miltiorrhiza,magnolia,lingzhi,and coptis had poten-tial therapeutic effects.The main effects of these drugs were regulation of the spleen,stomach,lung and other meridians,resulting in activation of blood circulation and removal of blood stasis,tonifying qi,and dispelling dampness.Conclusions Psoriasis and obesity share 13 common core target genes,which are associated with persistent inflammation and vascular changes.The predic-ted traditional Chinese medicine provides a basis for its utility in the treatment of psoriasis with o-besity.

psoriasisobesitybioinformaticstraditional Chinese medicine

徐玲云、张峻岭

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天津中医药大学研究生院,天津 301617

天津市中医药研究院附属医院,天津 300120

银屑病 肥胖 生物信息学 中药

广东省重点领域科研项目

2020B1111100005

2024

皮肤性病诊疗学杂志
广东省皮肤性病防治中心

皮肤性病诊疗学杂志

影响因子:0.666
ISSN:1674-8468
年,卷(期):2024.31(10)