摘要
报告原发性皮肤边缘区B细胞淋巴瘤1例.患者男,23岁,因背部红色结节5年就诊.皮肤科检查:背部多发大小不一红色结节,约5 mm ×5 mm～10 mm × 15 mm,表面光滑,边界清,未见明显鳞屑,质地较软,无压痛.皮损组织病理示:真皮层及皮下组织淋巴组织增生呈结节状分布,部分滤泡萎缩,其周围及小汗腺周围可见小-中等的中心细胞样及单核细胞样细胞围绕,局部侵及皮下脂肪组织.免疫组化示:CD20(+)、CD21(FDC 网+)、CD23(FDC 网+)、kappa(+)、Bcl-2(+)、CD43(部分+)、Ki-67(10％+),CD3、CD4、CD5、CD8、Lambda、Bcl-6、Cyclin-D1 均阴性.诊断:原发性皮肤边缘区 B 细胞淋巴瘤.患者放弃治疗,1年后失访.
Abstract
We report a case of primary cutaneous marginal zone B-cell lymphoma.A 23-year-old male presented with red nodules on his back for 5 years.Physical examination revealed multi-ple demarcated red nodules on the back,sized 5 mm × 5 mm to 10 mm × 15 mm,with smooth sur-face,soft texture,but without scales and tenderness.Histopathology showed nodular lymphoid hy-perplasia in the dermis and subcutaneous tissue,partial follicular atrophy,and small-to medium-sized centrocytoid and monocytoid cells surrounding the follicles and eccrine glands,which locally infiltrated into the subcutaneous adipose tissue.Immunohistochemistry revealed positive for CD20,CD21(FDC network),CD23(FDC network),kappa,Bcl-2,CD43(partially),Ki-67(10％),and negative for CD3,CD4,CD5,CD8,Lambda,Bcl-6 and Cyclin-D1.The diagnosis was pri-mary cutaneous marginal zone B-cell lymphoma.The patient declined the treatment and was lost follow-up 1 year later.
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