摘要
蕈样肉芽肿是原发于皮肤记忆性辅助T细胞的非霍奇金淋巴瘤,是皮肤T细胞淋巴瘤最为常见的亚型.大细胞转化是原发性皮肤T细胞淋巴瘤的一种特殊形式.其病因及发病机制尚不明确,临床表现及辅助检查无特异性.目前对患者是否需要积极治疗具有争议.本文系统性回顾蕈样肉芽肿伴大细胞转化的病因及发病机制、临床表现、诊断、治疗进展及预后,为临床医生对该病的认识、诊断和治疗提供帮助.
Abstract
Mycosis fungoides is a non-Hodgkin lymphoma originating from skin-resident memo-ry helper T cells,representing the most common subtype of cutaneous T-cell lymphoma.Large cell transformation is a unique form of primary cutaneous T-cell lymphoma with unclear etiology and pathogenesis.Clinical manifestations and auxiliary examinations lack specificity.Whether patients need aggressive treatment is controversial.This article systematically reviews the etiology,patho-genesis,clinical manifestations,diagnosis,treatment,and prognosis of mycosis fungoides with large cell transformation,offering insights for its diagnosis and management.
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