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托法替布治疗慢性光化性皮炎的研究进展

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慢性光化性皮炎(CAD)是一组以光敏感为特征的免疫介导疾病,托法替布作为Janus激酶(JAK)1/3抑制剂,是目前治疗CAD的JAK抑制剂中文献报道最多、应用较广泛的代表性药物.本文旨在综述托法替布治疗慢性光化性皮炎的机制、常用治疗剂量、具体疗效及不良反应情况等,并与其他JAK抑制剂进行对比.
Research progress on tofacitinib in the treatment of chronic actinic dermatitis
Chronic actinic dermatitis(CAD)is a group of immune-mediated diseases charac-terized by photosensitivity.Tofacitinib,a Janus kinase(JAK)1/3 inhibitor,is currently the most extensively reported and widely used JAK inhibitor for the treatment of CAD.This article aims to briefly overview the background of CAD and tofacitinib,as well as to summarize the mechanisms of tofacitinib in the treatment of chronic actinic dermatitis,commonly used therapeutic dosages,spe-cific efficacy,and adverse effects.Additionally,a brief comparison of tofacitinib with other JAK inhibitors is also included.

chronic actinic dermatitistofacitinibJAKsmall-molecule inhibitors

吴慧、沈郝佳、何泽枝、陈教全、李润祥、朱慧兰

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广州市皮肤病医院,广东 广州 510095

广州医科大学,广东 广州 511495

慢性光化性皮炎 托法替布 Janus激酶 小分子抑制剂

2024

皮肤性病诊疗学杂志
广东省皮肤性病防治中心

皮肤性病诊疗学杂志

影响因子:0.666
ISSN:1674-8468
年,卷(期):2024.31(12)