Network pharmacology study on the antioxidant effects of quercetin
The experiment aims to explore the antioxidative mechanism of quercetin based on network pharmacology methods,providing a reference for further research on the antioxidative effects of quercetin in laying hens.Search for the active ingredients and targets of quercetin in the Herb2.0 database,identify antioxidant targets and protein-protein interaction networks(PPI)in the Genecards database,and utilize the Metascape platform for target gene GO functional enrichment and KEGG pathway enrichment.The results showed that quercetin shares 122 common targets with antioxidants,including 32 key targets such as CCND1,MAPK3,CASP3,HIF1A,and VEGFA.GO enrichment analysis included 5 022 biological processes(BP),675 molecular functions(MF),and 421 cellular components(CC).KEGG enrichment analysis identified 250 pathways.The study indicates that quercetin mainly exerts its antioxidant effects by modulating pathways related to cancer,the advanced glycation end products-receptor for advanced glycation end products(AGE-RAGE)signaling pathway,lipid metabolism,and atherosclerosis.
NETL
NSTL
万方数据
