Research progress on the regulation of biofilm formation in avian pathogenic Escherichia coli by two-component systems
Avian pathogenic Escherichia coli is a typical extraintestinal pathogenic Escherichia coli that can cause various extraintestinal diseases,leading to significant economic losses in the poultry farming industry.Biofilm,serving as a physical barrier to protect bacteria from antibiotic damage and immune system evasion,contributes to persistent and recurrent infections in hosts.Two-component systems are prevalent signal transduction systems in various bacteria,playing a crucial role in regulating bacterial antibiotic resistance and biofilm formation.To understand the mechanisms of avian pathogenic Escherichia coli infection caused by biofilm,the article elaborates on the process of biofilm formation and provides a comprehensive review of the molecular mechanisms by which two-component systems regulate biofilm formation.The goal is to explore new approaches to disrupt biofilm formation by blocking two-component system signal transduction as a therapeutic strategy for controlling avian pathogenic Escherichia coli infections.The research direction aims to contribute to the prevention and treatment of antibiotic resistance caused by biofilm and persistent or recurrent infections.
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