The purpose of the study was to study the effect of EPP on NAFLD mice.Sixty-five C57BL/6 mice were randomly divided into five groups,13 mice in each group,which were the control group(NCD group),high fat group(HFD group)and high fat+EPP low,medium and high dose groups(HFD+EPP-L group,HFD+EPP-M group,HFD+EPP-H group).Mice in the NCD group were fed 10%fat diet,mice in HFD group were fed 60%fat high fat diet to induce NAFLD model,and mice in EPP administration group were fed high fat diet to induce NAFLD model.At the same time,different concentrations of EPP(0.5,1.0,2.0 g/kg)were given.After 12 weeks of continuous intervention,body weight,liver index,epididymal fat index,blood lipid and liver function indexes were measured,and the liver was examined by microscopy after hematoxylin-eosin staining.The results showed that compared with the NCD group,the body weight,liver index and epididymal fat index of the HFD group were extremely increased(P<0.01),the contents of serum TC,TG,LDL-C were extremely increased(P<0.01),the activities of serum ALT and AST were extremely increased(P<0.01),and the contents of HDL-C were extremely decreased(P<0.01).Compared with the HFD group,the degree of hepatic steatosis in the HFD+EPP-L group and HFD+EPP-H group decreased,and the body weight decreased significantly or extremely significantly at the 5th and 6th weeks after EPP intervention,respectively(P<0.05 or P<0.01).Compared with the HFD group,liver index,epididymal fat index,serum TC,TG,LDL-C content and AST,ALT activity in the HFD+EPP-L group were extremely decreased(P<0.01),while HDL-C content was significantly increased(P<0.05).Studies have shown that EPP can improve the weight gain,liver fat deposition,blood lipid and liver function level induced by high-fat diet in NAFLD mice,and has a certain therapeutic effect on NAFLD.
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