Exploring molecular mechanism of dark plum in the treatment of Crohn's disease based on network pharmacology and molecular docking
The aim of this experiment was to explore the target and mechanism of dark plum therapy for CD by using data mining method.TCMSP database was used to screen and search the main active components in dark plum,Swiss Target Prediction software and GeneCards database were used to predict the corresponding target of active components and CD,and the PPI network was constructed using Cytoscape 3.7.2 software.Key targets were imported into the DAVID database for GO function analysis and KEGG signal path enrichment analysis.Finally,Autodock software was used to perform molecular docking between key targets of CD and main components of dark plum.The results showed that a total of 26 potential active components were selected,and there were 156 common targets between the two components.A total of 283 biological processes were obtained by GO analysis,and 35 signaling pathways were identified by KEGG enrichment analysis.The results of molecular docking showed that the active ingredients of dark plum and CD target docking is good.The study showed that the active components of dark plum could interact with the related target proteins of CD,and showed the characteristics of multi-components,multi-targets and multi-pathways.
NETL
NSTL
万方数据
