Mitigating effect of total flavonoid from Abrus cantoniensis Hance extract on aflatoxin B1-induced hepatic injury in chickens
The purpose of the study was to ACE could alleviate the hepatotoxicity induced by AFB1,and to provide a new idea for clinical prevention and treatment of liver injury induced by AFB1.60 healthy Sanhuang chickens were randomly divided into three groups,and four replicates in each group with five chickens in each replicate.Chickens in the blank control group(NC group)were fed basal diets,AFB1 group were fed basal diets plus 2.8 mg/kg AFB1,and ACE group were fed basal diets plus 2.8 mg/kg AFB1+1 g/kg ACE.The experiment lasted for seven days.The results showed that compared with the NC group,the body weight,liver GST expression,liver CAT,SOD,and GSH-Px activities of the AFB1 group decreased significantly(P<0.05),serum AST,ALT,ALP and GGT activities,liver MDA content,and liver CYP1A2 expression increased significantly(P<0.05).Compared with the AFB1 group,the body weight,liver GST expression and activities of CAT,SOD and GSH-Px in the ACE group increased significantly(P<0.05),while serum AST,ALT,ALP and GGT activities,liver MDA content,and liver CYP1A2 expression in the ACE group decreased significantly(P<0.05).Studies have shown that dietary ACE supplementation may play a synergistic role by enhancing antioxidant capacity and inhibiting the activation of AFBO mediated by AFB1,which is a key CYP450 isozyme,thus protecting chickens from AFB1-induced liver injury.
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