弓形虫入侵过程中主要分泌蛋白的研究进展
Research progress of major secreted proteins during Toxoplasma gondii invasion
孟欣 1徐丰慧 1崔平1
作者信息
- 1. 河北北方学院,河北 张家口 075000
- 折叠
摘要
弓形虫是顶复门的一种专性细胞内寄生虫.该寄生虫寄生于宿主体内时,利用一系列分泌蛋白完成其入侵过程.弓形虫入侵宿主过程的关键蛋白包括:前端的微线体蛋白(MICs),参与形成顶端复合体;棒状体蛋白(ROPs),协助建立细胞内环境;致密颗粒蛋白(GRAs),调节入侵过程中多个步骤.文章综述了弓形虫入侵过程中主要的分泌蛋白,并对弓形虫疫苗的未来发展进行了前瞻性思考,以期为探索弓形虫的致病原理及为疫苗开发提供参考.
Abstract
Toxoplasma gondii is an obligate intracellular parasite of the parietal phylum.The parasite uses a series of secreted proteins to complete its invasion of the host.Key proteins involved in Toxoplasma gondii's host invasion process include:Microfilament proteins(MICs)at the front end,which participate in the formation of apical complex;Rod body proteins(ROPs),which help to establish intracellular environment;Dense particle proteins(GRAs),which regulate multiple steps in the invasion process.In the paper,the main secreted proteins during the invasion of Toxoplasma gondii were summarized,and the future development of Toxoplasma gondii vaccine was prospectively considered,in order to provide a reference for exploring the pathogenic principle of Toxoplasma gondii and developing vaccines.
关键词
弓形虫/入侵过程/分泌蛋白/疫苗Key words
Toxoplasma gondii/Intrusion process/Secretory protein/Vaccine引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据