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犬特异性皮炎药物研发进展

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特异性皮炎是犬类中常见的过敏性皮肤病之一,其症状主要表现为炎症、瘙痒、皮肤损伤和感染等,临床中以采用药物治疗为主要手段,但目前可供选择的药物仍然十分有限.为了更全面地了解犬特异性皮炎的药物治疗研究进展,文章剖析了该病的发病机制和相关危险因素,并在此基础上系统地综述了目前临床中常用的治疗药物,包括糖皮质激素、抗组胺药、钙调神经磷酸酶抑制剂、必需脂肪酸、Janus激酶(JAK)抑制剂、动物干扰素和犬化白细胞介素-31(IL-31)抗体等.通过总结犬特异性皮炎的发病特点、致病因素和临床用药进展,指出这些药物仍然存在的局限性与不足之处,以期为犬特异性皮炎的药物研发提供新的方向,找到更加有效、安全的治疗方法.
Advances in drug development for canine atopic dermatitis
Canine atopic dermatitis is one of the common allergic skin diseases in dogs,characterized mainly by inflammation,itching,skin damage,and infection.Clinical treatment primarily relies on medication,but there is still a limited selection of drugs available.To provide a comprehensive understanding of the research progress in drug treatment for canine atopic dermatitis,this article analyzes the pathogenesis and related risk factors of the disease and systematically reviews the commonly used therapeutic drugs,including corticosteroids,antihistamines,calcineurin inhibitors,essential fatty acids,Janus kinase(JAK)inhibitors,canine interferons,and canine interleukin-31(IL-31)antibodies.By summarizing the characteristics,pathogenic factors,and clinical medication advances of canine atopic dermatitis,the article points out the limitations and deficiencies of these drugs,aiming to provide new directions for drug development and find more effective and safe treatment methods.

CanineAtopic dermatitisSkin diseasesVeterinary drug research and development

姚含悦、张金泉、杨海龙

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赣南医科大学赣南创新与转化医学研究院重大疾病新药靶发现及新药创制全国重点实验室,江西 赣州 341000

特异性皮炎 皮肤病 兽药研发

江西省国际科技合作项目

20232BBH80011

2024

现代畜牧兽医
辽宁省畜牧兽医学会 辽宁省动物卫生监测预警中心

现代畜牧兽医

影响因子:0.316
ISSN:1672-9692
年,卷(期):2024.(8)