Advances in molecular mechanisms of cardiac cell death induced by alcohol
Ethanol(alcohol)has multiple effects on the cardiovascular system,long-term alcohol abuse can cause sig-nificant cardiotoxic effects,ethanol and its metabolites may trigger alcoholic cardiomyopathy,and even lead to sudden death.This toxic effect may be related to a variety of mechanisms,including mitochondrial dysfunction,oxidative stress in-jury,protein synthesis impairment,catabolism abnormalities,fatty acid metabolism disorders,etc.These mechanisms in-teract and ultimately lead to cell death.Cell death is one of the important mechanisms of myocardial injury and dysfunction caused by alcohol,which has been verified in acute and chronic alcohol animal models and cardiac specimens of alcoholic cardiomyopathy patients.This paper elaborated and summarized the molecular mechanisms of apoptosis,autophagy,iron death,necrotic apoptosis,pyrodeath and other cell death modes in the process of alcohol-induced myocardial injury,aim-ing to further explore the pathogenesis of alcohol-induced heart damage,in order to provide some new intervention targets and treatment plans for alcohol-induced heart damage.
ethanolmyocardial injuryalcoholic cardiomyopathycell death
NETL
NSTL
万方数据
维普
