摘要
目的 探讨老年帕金森病患者衰弱的危险因素.方法 选取2014年9月—2024年2月在四川大学华西医院住院的147例老年帕金森病患者,根据FRAIL评分结果将患者分为衰弱和非衰弱,采用单因素分析和二元lo-gistic回归分析,探讨老年帕金森病患者衰弱发生的危险因素.结果 147例老年帕金森病患者中,有58例(39.4%)患者存在衰弱.衰弱、非衰弱老年帕金森病患者年龄、BMI、D-二聚体、血小板、白蛋白、Barthel评分、疼痛数字评分(NRS)、华西跌倒评分比较差异有统计学意义(P均<0.05).二元logistic回归分析显示:BMI(OR=0.777,95%CI:0.679～0.889)、白蛋白(OR=0.773,95%CI:0.773～0.933)、Barthel评分(OR=0.981,95%CI:0.967～0.995)、NRS(OR=1.529,95%CI:1.132～2.067)是老年帕金森病患者衰弱发生的影响因素(P均<0.05).结论 老年帕金森病患者衰弱发生率相对较高,低BMI、低白蛋白、低Barthel评分、高NRS是老年帕金森病患者衰弱发生的危险因素.
Abstract
Objective To identify the risk factors associated with frailty in elderly individuals diagnosed with Parkin-son's disease.Methods A total of 147 elderly Parkinson's disease patients who were hospitalized in West China Hospi-tal of Sichuan University between September 2014 and February 2024 were selected.Based on their FRAIL score results,participants were categorized into frail and non-frail groups.Univariate analysis and binary logistic regression were employed to examine the risk factors for frailty in this population.Results Among of the 147 patients,58(39.4%)were identified as frail.Significant differences were observed in age,body mass index(BMI),D-dimer levels,platelet count,albumin levels,Barthel score,NRS,and Huaxi Fall Assessment scale between the frail and non-frail groups(all P<0.05).The binary logistic regression analysis indicated that BMI(OR=0.777,95%CI:0.679-0.889),albumin levels(OR=0.773,95%CI:0.773-0.933),Barthel score(OR=0.981,95%CI:0.967-0.995),and NRS(OR=1.529,95%CI:1.132-2.067)were significant factors influencing frailty in elderly Parkinson's patients(all P<0.05).Conclusions The preva-lence of frailty among elderly patients with Parkinson's disease is notably high.Factors such as low BMI,low albumin lev-els,low Barthel scores,and high NRS are identified as risk factors for frailty in this demographic.
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