The relationship between osteoarthritis and Alzheimer's disease:bidirectional Mendelian randomization study
Objective To investigate the possible causal relationship between osteoarthritis and Alzheimer's dis-ease.Methods Data on osteoarthritis and Alzheimer's disease were obtained from the Genome-Wide Association Studies summary statistics.Use the bidirectional Mendelian randomization analysis,strictly screen the instrumental variables,and the inverse variance weighting method(IVW)was used as the main method,combined with weighted median,MR-Egger regression and weighted model method for analysis.To ensure the robustness of the results,three sensitivity analyses in-cluding MR-Egger intercept test,Cochran's Q test and leave-one-out analysis were used to assess pleiotropy and heterogene-ity.Results IVW analysis showed that there was a causal effect between genetic susceptibility to osteoarthritis and risk of Alzheimer's disease(OR=19.887,95%CI:2.896-136.568,P=0.002).However,there was no correlation between genetic susceptibility to Alzheimer disease and the risk of osteoarthritis(OR=1.001,95%CI:0.999-1.003,P=0.422).Conclusion Osteoarthritis can increase the risk of developing Alzheimer's disease,and Alzheimer's disease does not in-crease the risk of developing osteoarthritis.
osteoarthritisAlzheimer's diseaseMendelian randomizationgenome-wide association analysisin-verse variance weighting
万方数据
维普
