To enhancethe understanding of exogenous insulin autoimmune syndrome,the diagnosis and treatment of an elderly diabetic patient with recurrent hypoglycemia were reviewd.Laboratory tests showed increased insulin and C-pep-tide with dissociation,positive insulin autoantibody(IAA)and serum islet cell antibody(ICA);and genetic testing showed a point mutation in the CD3E gene.It was hypothesized that the patient's recurrent hypoglycemia might be related to his au-toimmune characteristics and long-term application of exogenous insulin.
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