Causal effect between asthma and sarcopenia:a bidirectional Mendelian randomization study
Objective To explore the causal effect between asthma and sarcopenia by means of a Mendelian randomiza-tion(MR)study.Methods Two-sample MR method was used to evaluate the causal relationship between asthma dataset and three datasets associated with sarcopenia(low hand grip strength,limb muscle weight,and walking speed).The results of in-verse variance weighting method were used as the main indicators,and the MR-Egger regression,weighted median value,sim-ple mode-based estimation and mode-based weighted estimation were used as the references.The stepwise elimination method was used to test sensitivity,the Q test was used to test heterogeneity,and the MR pleiotropy function was used to test pleiotro-py.The reverse MR study was conducted to investigate the effect of sarcopenia on asthma.Results Asthma was associated with an increased probability of low hand grip strength(OR =1.703,95% CI:1.206-2.405,P =0.003),decreased limb muscle weight(OR = 0.733,95% CI:0.598-0.899,P =0.003),and decreased walking speed(OR = 0.930,95% CI:0.873-0.990,P =0.022).The stepwise elimination method confirmed that the causal effect of asthma on the 3 datasets of sar-copenia was stable.The reverse study did not find any promoting effect of sarcopenia on asthma.Conclusion Asthma pro-motes the occurrence and development of sarcopenia,and is a potential adverse factor for sarcopenia.
国家科技期刊平台
NSTL
万方数据
维普
