Mendelian randomization analysis of causal relationship between sarcopenia and atrial fibrillation in the elderly
Objective This study used mendelian randomization(MR)to investigate the causal relationship between sarcopenia and the risk of atrial fibrillation,providing a theoretical basis for the prevention and treatment of atrial fibrillation in elderly.Methods Based on the dataset from the Genome Wide Association Study(GWAS),the characteristic indicators of sarcopenia including left hand grip strength,right hand grip strength,and appendicular lean mass(ALM)were used as the ex-posure factors for sarcopenia,and AF were used as the outcome.The causal effects of left hand grip strength,right hand grip strength and ALM on AF were evaluated by MR.Results The results of the inverse variance weighted(IVW)analysis showed that left hand grip strength(OR = 0.782,95%CI:0.677～0.904,P＜0.001),right hand grip strength(OR = 0.646,95%CI:0.558～0.748,P＜0.001),and ALM(OR =0.769,95%CI:0.739～0.799,P＜0.001)were associated with a reduced risk of AF,and there was no heterogeneity or validity in the results.Conclusion An increase in left hand grip strength,right hand grip strength,and ALM may be useful for prevent and treat AF.
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