Influence factors for frailty in elderly patients with ischemic stroke and their relationship with nutritional status and cognitive function
Objective To explore the influence factors for frailty and its relationship with nutritional status and cognitive function in elderly patients with ischemic stroke(IS).Methods A total of 146 elderly IS patients admitted to Second People's Hospital of Lianyungang City,Jiangsu Province from January 2019 to January 2021 were retrospectively selected as the study subjects.According to presence or absence of frailty,they were divided into frailty group and non-frailty group.The clinical data,nutritional status and cognitive function of the two groups were compared.The correlation between frailty and nutritional status and cognitive function was analyzed by Pearson correlation analysis,and the influencing factors for frailty were analyzed by logistic regression analysis.Results A total of 146 elderly IS patients were included,of which 41 ones experienced frailty,with an incidence of 28.05%.The scores of MNA-SF and MMSE of the frailty group were lower than those of the non-frailty group(t =3.454;t =5.161,P＜0.05).Pearson correlation analysis showed that FRAIL score was negatively correlated with MNA-SF and MMSE scores(r =-0.456;r =-0.503,P＜0.05),while MNA-SF score was positively correlated with MMSE score(r =0.488,P＜0.05).The proportion of patients in the frail group with age≥75 years old,renal insufficiency,NIHSS score≥15 points at admission,HAMD score≥7 points,MNA-SF score＜8 points,MMSE score＜25 points were high-er than those in the non-frail group(P＜0.05).Multivariate Logistic analysis showed that age≥75 years(OR = 2.700,P =0.045),HAMD score≥7 points(OR =4.399,P =0.002),albumin＜35 g/L(OR =5.057,P =0.001),MNA-SF score＜8 points(OR =3.433,P =0.015)and MMSE score＜25 points(OR =4.155,P =0.013)were independent risk fac-tors for frailty in elderly IS patients(P＜0.05).Conclusion The incidence of frailty is higher in elderly IS patients,which may be related to malnutrition and cognitive dysfunction.
elderlyischemic strokefrailtynutritional statuscognitive function
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