A preliminary quantitative study of gamma-aminobutyric acid/glutamate in auditory cortex of elderly tinnitus patients by MR spectral imaging
Objective To measure the content of neurotransmitter(gamma-aminobutyric acid/glutamate,GABA/Glu)in the auditory cortex of elderly patients with primary tinnitus and gender-and age-matched subjects without tinnitus by magnetic resonance spectroscopy(MRS),and compare the differences of various metabolites and their correlation with clinical scores.Methods 30 elderly patients with primary tinnitus(tinnitus group)and 32 gender-and age-matched subjects without tinnitus(control group)who visited Huadong Hospital Affiliated to Fudan University from October 2022 to October 2023 were collect-ed.The contents of metabolites in the auditory cortex of all subjects were detected by MRS.Correlation analysis was conducted between their detected values and the scores of Tinnitus Handicap Inventory(THI)and Insomnia Severity Index(ISI).Results Compared with the control group,the level of Glu in the right auditory cortex of the tinnitus group was significantly higher(P＜0.05).The level of Glu in the right auditory cortex of tinnitus patients was significantly positively correlated with THI score(r =0.490,P＜0.05).Conclusion The level of Glu in the right auditory cortex of elderly tinnitus patients in-creased significantly,and was significantly positively correlated with THI score.It suggests that the onset and pain level of tin-nitus may be potentially related to the increase of excitatory transmitters.
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