A study of application of surgical pleth index to guide analgesia in elderly colon cancer patients undergoing surgery
Objective To explore whether surgical pleth index(SPI)can guide the precise use of analgesic drugs in elderly patients under general anesthesia.Methods A total of 60 elderly patients scheduled for elective colon cancer surgery were selected and grouped according to random numbers generated by SPSS,with 30 cases in each group.The control group(group C)used sufentanil based on the experience of anesthesiologists,while the experimental group(group T)used sufen-tanil under the guidance of SPI.The general conditions of the two groups were collected.MBP and HR at the time of admission to the operating room,tracheal intubation,the beginning of the operation,the end of the operation,and 5 min after extubation of the two groups were recorded.The operation time,extubation time,and dosage of sufentanil during surgery and PACU of the two groups were recorded.The numerical pain scores[assessed by Numerical Rating Scale(NRS)]of the two groups of patients were also recorded when they were able to communicate awake and when they discharged from PACU.The levels of serum IL-6 and IL-10 were detected before and after operation.Results There were no differences in the general condition,operation time and extubation time between the two groups(P＞0.05).There was no significant difference in MBP and HR between the two groups at each time point(P＞0.05).The dosage of sufentanil in the group T was more than that in the group C during the operation and less than that in the group C during PACU(P＜0.05),and the two NRS scores of the group T were lower than those of the group C(P＜0.05).The difference in the levels of serum IL-6 and IL-10 between the two groups be-fore operation was not statistically significant(P＞0.05),while the differences after operation were statistically significant(P＜0.05).Compared with the same group before operation,serum IL-6 level in both groups increased after operation,but the difference in the group C was statistically significant(P＜0.05),while the difference in group T was not statistically signif-icant(P＞0.05).Compared with the same group before operation,the serum IL-10 level in the group C decreased after opera-tion,but increased in the group T,and the difference was statistically significant(P＜0.05).Conclusion SPI can effectively guide the precise use of analgesics in elderly patients under general anesthesia during colon cancer surgery,provide appropriate analgesia levels,and reduce intraoperative stress reactions and adverse complications during recovery.
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