Effects of dapagliflozin combined with other hypoglycemic drugs on elderly patients with diabetic kidney disease and function of pancreatic islet β-cells
Objective To explore the effects of dapagliflozin combined with other hypoglycemic drugs on elderly pa-tients with diabetic kidney disease(DKD)and the function of pancreatic islet β-cells.Methods 100 elderly DKD patients with complete data who were hospitalized in People's Hospital of Hai'an City from October 2020 to May 2023 were selected and divided into observation group and control group by random number table method,with 50 cases in each group.The control group was treated with metformin extended-release tablets,acarbose tablets and irbesartan tablets,while the observation group was treated with dapagliflozin on the basis of the control group.The blood glucose levels[fasting blood glucose(FBG),2-hour postprandial blood glucose(2-hour PBG),and glycated hemoglobin A1c(HbA1c)],renal function index values[24-hour urinary protein quantification(24-UP),blood urea nitrogen(BUN),glomerular filtration rate(GFR)],and pancreatic islet β-cell function evaluation values[C-peptide,homeostasis model of IR index,homeostasis model of islet β-cell function index(HOMA-β)],and the incidence of major adverse cardiovascular events(MACE)[heart failure readmission(HFR),non-fatal myocardial infarction,angina]were observed and compared between the two groups.Results After treatment,the blood glucose levels of the two groups were significantly lower than those of the same group before treatment,and the observa-tion group was significantly lower than the control group,with statistical significance(P＜0.05);the levels of 24-UP,BUN,C-peptide and HOMA-IR of the two groups were lower than those of the same group before treatment,and the observation group was significantly lower than the control group,with statistical significance(P＜0.05);the HOMA-β of the two groups were significantly higher than those of the same group before treatment,and the observation group was significantly higher than the control group,with statistical significance(P＜0.05).There was no significant difference in GFR between the two groups before and after treatment(P＞0.05).The incidence of MACE in the observation group was significantly lower than that in the control group(P＜0.05).Conclusion The combination of dapagliflozin with other hypoglycemic drugs can improve renal function,blood glucose indicators,and pancreatic islet β-cell function in elderly DKD patients,and reduce the risk of MACE.
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