Comparison of safety and efficacy of preemptive analgesia with different administration methods of butorphanol in elderly patients undergoing laparoscopic cholecystectomy
Objective To compare the safety and efficacy of preemptive analgesia with different administration methods of butorphanol in elderly patients undergoing laparoscopic cholecystectomy.Methods 150 elderly patients undergoing laparo-scopic cholecystectomy under general anesthesia in Central Hospital of Jingmen City from June 2021 to June 2022 were selected.They were divided into control group(group C),intravenous injection group(groupⅣ)and nasal spray group(group NS)ac-cording to random number table method,with 50 cases in each group.10 minutes before surgery,group C,groupⅣ,and group NS were given an equal volume of normal saline via intravenous injection,0.5 mg of butorphanol via intravenous injection,and 0.5 mg of butorphanol via nasal spray,respectively.HR and MAP of patients were recorded before administration(T0),imme-diately after intubation(T1),immediately after pneumoperitoneum(T2)and immediately after extubation(T3).The incidence of adverse reactions,rate of postoperative salvage analgesia,recovery time after discontinuation of medication,and VAS score were compared among the three groups.Results Compared with the same group at T0,the group C showed a significant in-crease in HR and MAP at T1-T3(P＜0.05).Compared with the group C,both groupⅣand group NS showed a significant in-crease in HR and MAP at T1-T3(P＜0.05).Compared with the group C,the incidence of postoperative injection pain,coug-hing,nausea,vomiting,and the rate of postoperative addition of sufentanil in the groupⅣand group NS decreased significantly(P＜0.05).The incidence of dizziness in the group Ⅳwas significantly higher than that in the group C and group NC(P＜0.05).Compared with the group C,the VAS scores at the moment of awakening in the groupⅣand group NS were significantly lower(P＜0.05).Conclusion Preoperative preemptive analgesia with butorphanol can make the intraoperative hemodynamics of patients stable,reduce the application of postoperative opioids,and reduce postoperative adverse reactions.Some patients expe-rienced dizziness after intravenous butorphanol injection,but no patients experienced dizziness after nasal spray administration.
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