Objective To explore the influence factors of perioperative malnutrition in elderly patients with oral cancer and the effects of immunonutrition support.Methods A total of 166 elderly patients with oral cancer who underwent radical operation in People's Hospital of Langfang City from January 2021 to August 2023 were enrolled as the study subjects.The perioperative nutritional status of patients was assessed by the Patient Generated Subjective Global Assessment(PG-SGA),and they were divided into malnutrition risk group and normal nutrition group.The clinical data of the two groups were compared.Logistic regression method was used to analyze the influencing factors of perioperative malnutrition in elderly patients with oral cancer.Patients in the malnutrition risk group received immunonutrition support therapy after surgery.The levels of nutritional indexes[serum albumin(ALB),total protein(TP),transferrin(TRF),prealbumin(PAB),hemoglobin(Hb),vitamin B12,folate]and immune indexes[immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)]in the two groups were statistically analyzed before surgery and at 2 weeks after surgery.Results Among 166 elderly patients with oral cancer included in this study,131 were at risk of malnutrition,with an incidence of 78.92％.Binary Logistic analysis showed that smoking,clinical stage Ⅲ～Ⅳ and preoperative comorbidities were independent risk factors for perioperative mal-nutrition in elderly patients with oral cancer(P＜0.05).The levels of BMI,ALB,TP,TRF,PAB,Hb,vitamin B12,and folate in the malnutrition risk group after 2 weeks of treatment were higher than those of the same group before treatment(P＜0.05).The levels of IgG,IgA and IgM in the malnutrition risk group after 2 weeks of treatment were also higher than those of the same group before treatment(P＜0.05).There was no significant difference in the total incidence of adverse reactions be-tween the two groups(P＞0.05).Conclusion The risk factors for malnutrition in elderly oral cancer patients may mainly in-clude smoking,clinical stages Ⅲ～Ⅳ,and preoperative complications.Immunonutrition support can effectively improve nutri-tional status and immune function in elderly patients with oral cancer and malnutrition.
elderlyoral cancermalnutritionimmunonutrition support
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