A study on relationship between polymorphism of leptin receptor gene rs1137101 locus and risk of metabolic-associated fatty liver disease in elderly population
Objective To investigate the relationship between polymorphism of leptin receptor gene rs1 137101 locus and risk of metabolic-associated fatty liver disease(MAFLD)in the elderly.Methods From January 2020 to September 2021,1 019 elderly volunteers were recruited from Mentougou Community in Beijing for physical examination,including 569 ones in the MAFLD group and 450 ones in the non-MAFLD group.Their clinical data were recorded,and the genotype of LEPR-rs1137101 polymorphism was detected by gene chip.Logistic regression analysis was used to evaluate the relationship be-tween gene polymorphism and the occurrence of MAFLD.Results Among the elderly population,rs1 137101 G＞A polymor-phism was more common in the MAFLD group than that in the non-MAFLD group(36.91％vs 24.00％,P＜0.05).The LEPR-rs1 137101 A allele was associated with an increased risk of MAFLD(OR=1.695,95％CI:1.140-2.520,P＜0.05).Conclusion LEPR-rs1 137101 A gene may be related to the occurrence of MAFLD in the elderly population.
国家科技期刊平台
NSTL
万方数据
