Study on correlation between SIRI,SII,liver fibrosis level and poor prognosis in elderly patients with chronic and subacute liver failure
Objective To investigate the correlation between systemic inflammation response index(SIRI),systemic immune-inflammation index(SII),liver fibrosis level and poor prognosis in elderly patients with chronic and subacute liver failure.Methods A total of 105 elderly patients with chronic and subacute liver failure admitted to Shengjing Hospital Affilia-ted to China Medical University from March 2019 to June 2023 were selected as the study subjects.They were divided into good prognosis group(n=72)and poor prognosis group(n=33)according to their prognosis after treatment.The SIRI,SII and liver fibrosis factor 4 index(FIB-4)were compared between the two groups.Binary logistic regression analysis was used to screen the important risk factors for poor prognosis in elderly patients with chronic and subacute liver failure.Results The lev-els of alanine aminotransferase,aspartate aminotransferase,SIRI,SII and FIB-4 in the poor prognosis group were significantly higher than those in the good prognosis group,and the lymphocyte count was significantly lower than that in the good prognosis group(all P＜0.05).Univariate and multivariate Logistic regression analysis showed that high levels of SIRI,SII,and FIB-4 were important risk factors for elderly patients with chronic and subacute liver failure(P＜0.05).Conclusion SIRI,SII and FIB-4 can be used as potential biological markers to evaluate the prognosis of elderly patients with chronic and subacute liver failure,which provides a basis for further construction of prognostic risk prediction models.
elderlychronic and subacute liver failuresystemic inflammation response indexprognosis
国家科技期刊平台
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