Predictive value of frailty for postoperative delirium,aspiration pneumonia and short-term prognosis in elderly lung cancer patients
Objective To explore the predictive value of frailty on postoperative delirium,aspiration pneumonia and 1-year mortality rate in elderly lung cancer patients.Methods 159 elderly patients with lung cancer who underwent surgery in Second Affiliated Hospital of Air Force Medical University from July 2021 to June 2023 were selected and divided into frailty group(n=56)and non-frailty group(n=103)according to their preoperative frailty scores.Univariate and multivariate logis-tic regression methods were used to analyze whether frailty was an independent risk factor for predicting postoperative delirium,aspiration pneumonia,and death within 1 year.Results Compared with the non-frailty group,the patients in the frailty group were older,had a higher proportion of patients with diabetes,higher proportion of ASA grade Ⅱ～Ⅲ,higher proportion of ECOG scores of 2～3,and higher proportion of blood transfusion(all P＜0.05).Compared with the non-frailty group,the incidence of postoperative delirium(19.42％vs 37.50％,P=0.01)and aspiration pneumonia(8.74％vs 19.64％,P=0.04),as well as the 1-year mortality rate(17.48％vs 33.93％,P=0.02),increased significantly in the frailty group.Uni-variate regression analysis showed that comorbid diabetes(OR=1.78,P=0.006),long operation time(OR=2.21,P=0.004),high tumor stage(OR=1.48,P=0.03),high ECOG scores(OR=2.05,P＜0.001),and frailty(OR=2.95,P=0.002)were risk factors for postoperative delirium,aspiration pneumonia and death within 1 year in elderly patients with lung cancer.Multivariate analysis suggested that comorbid diabetes(OR=1.50,P=0.007),high TNM stage(OR=1.88,P=0.01),high ECOG score(OR=2.90,P＜0.001),and frailty(OR=1.42,P=0.03)were the independent risk factors for postoperative delirium,aspiration pneumonia,and 1-year mortality in elderly patients with lung cancer.Conclusion The risk of postoperative delirium,aspiration pneumonia and death within one year may increase in elderly lung cancer patients com-plicated with frailty,which deserves clinical attention.
国家科技期刊平台
NSTL
万方数据
