Effects of CXC family chemokine level on prognosis and chemotherapy sensitivity in elderly patients with lung adenocarcinoma
Objective The purpose of this study was to screen prognostic related CXC family chemokines and evaluate the effect of their expression level on chemotherapy sensitivity in elderly patients with lung adenocarcinoma,so as to explore potential prognostic markers and provide reference for the formulation of individualized treatment strategies.Methods The case data of elderly patients with lung adenocarcinoma treated in Second Affiliated Hospital of Air Force Military Medical Uni-versity from April 2020 to April 2022 were selected for analysis.The level of serum CXC family chemokines(including CXCL1-CXCL17)were detected.The prognostic risk factors were screened by univariate and multivariate Cox analysis.Kap-lan-Meier curve and Log-rank test were used for survival analysis.Results Univariate Cox analysis showed that CXCL17,CXCL16,CXCL13 and CXCL8 were protective factors for good prognosis in patients with lung adenocarcinoma(HR＜1,P＜0.05).Multivariate Cox analysis showed that CXCL17 was an independent protective factor for good prognosis in patients with lung adenocarcinoma(HR=0.90,P=0.018).The prognosis of lung adenocarcinoma patients with high CXCL17 level was better than that of lung adenocarcinoma patients with low CXCL17 level(P=0.013).In lung adenocarcinoma patients with high level of CXCL17,chemotherapy did not significantly improve progression-free survival(P＞0.05).In lung adenocarci-noma patients with low level of CXCL17,chemotherapy could significantly improve progression-free survival(P＜0.001).In patients with low CXCL17 level,chemotherapy was a protective factor for good prognosis in patients with lung adenocarcinoma(HR=0.92,P=0.004).Conclusion CXCL17 may be an independent protective factor for good prognosis in patients with lung adenocarcinoma,and high CXCL17 level may predict longer progression-free survival.In lung adenocarcinoma patients with low CXCL17 level,chemotherapy is a protective factor for a good prognosis.CXCL17 may be a potential prognostic marker of lung adenocarcinoma,which can assist in the sorting of patients suitable for chemotherapy,and has certain clinical application value.
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