不同味觉刺激对老年人群吞咽相关大脑皮层激活模式的研究
Study on activation of cortical areas related to swallowing in elderly populationunder different taste stimulation
周哲 1陈芳元 1王亚芹 1赵苡雯 1陈志群 1田威 1龚雪莲 1郑洁皎2
作者信息
- 1. 上海市第一康复医院神经康复二科,上海 200090
- 2. 复旦大学附属华东医院康复医学科,上海 200040
- 折叠
摘要
目的 基于功能性近红外光谱技术探索不同味觉刺激对老年人群大脑皮层不同功能区激活的影响.方法 纳入2023年1月-2023年3月在上海市第一康复医院体检的19名老年受试者(平均年龄:70.7±7.2岁),在吞咽辣味溶液、酸味溶液和蒸馏水时,应用功能性近红外光谱成像技术记录双侧前额叶及双侧运动区的含氧血红蛋白浓度,分析在不同味觉吞咽任务下受试者大脑皮层激活模式的差异.结果 在吞咽酸味、辣味溶液时,可显著激活缘上回部分、前运动皮层和辅助运动区、背外侧前额叶、额下回后部、额极区、前额叶下回(P＜0.05),酸味溶液还显著激活了右侧初级运动皮层(P＜0.05);吞咽酸味溶液与吞咽蒸馏水相对比,右侧缘上回部分(P＜0.05)、双侧前运动皮层和辅助运动区(P＜0.05)、右侧背外侧前额叶(P＜0.05)、双侧额极区(P＜0.05)、右侧前额叶下回(P＜0.01)显著激活.吞咽酸味溶液与吞咽辣味溶液相对比,右侧前额叶下回显著激活(P＜0.05).结论 不同味觉刺激可影响老年人群吞咽相关大脑皮层激活,酸味刺激可促进右侧初级运动皮层的激活,可能对于老年人群吞咽障碍的防治具有潜在的应用价值.
Abstract
Objective To explore the effects of different taste stimulation on activation of different functional areas of cerebral cortex in elderly population based on functional near-infrared spectroscopy(fNIRS).Methods Nineteen elderly par-ticipants(mean age:70.7±7.2 years)who underwent health examinations in The First Rehabilitation Hospital of Shanghai from January to March 2023 were enrolled.When they swallowed spicy solution,sour solutionand and distilled water,fNIR-Simaging technologywas used to record the concentrations of oxygenated hemoglobin(HbO2)in bilateral prefrontal lobes and bilateral motor areas.The differences in cortical activation patterns of subjectsunder different taste swallowing tasks were ana-lyzed.Results When swallowing sour and spicy solutions,it could significantly activate the supramarginal gyrus part,premo-tor cortex and supplementary motor area,dorsolateral prefrontal cortex,posterior inferior frontal gyrus,frontopolar area,and inferior prefrontal gyrus(P＜0.05).The sour solution also significantly activated the right primary motor cortex(P＜0.05).Compared with swallowing distilled water,swallowing sour solution significantly activated the right supramarginal gyrus part(P＜0.05),bilateral pre-motor cortex and supplementary motor area(P＜0.05),right dorsolateral prefrontal lobe(P＜0.05),bilateral frontopolar area(P＜0.05),and right inferior prefrontal gyrus(P＜0.01).Compared with swallowing spicy solution,swallowing sour solution significantly activated the right inferior prefrontal gyrus(P＜0.05).Conclusion Different taste stimulation can affect the activation of the cerebral cortex related to swallowing in elderly population.Sour taste stimula-tion can promote the activation of the right primary motor cortex,which may have potential application value for the prevention and treatment of swallowing disorders in elderly people.
关键词
老年/吞咽/味觉刺激/功能性近红外光谱技术/皮层激活Key words
elderly/swallowing/taste stimulation/functional near-infrared spectroscopy/cortical activation引用本文复制引用
基金项目
上海市卫生健康委员会科研项目(201940392)
上海康复医学临床医学研究中心项目(21MC1930200)
上海市科委项目(22Y31900200)
上海市杨浦区双委课题(YPM202311)
出版年
2024
国家科技期刊平台
NSTL
万方数据