Clinical observation of moderate intensity interval training combined with metformin in treatment of elderly patients with type 2 diabetes mellitus
Objective To explore the effects of moderate intensity interval training(MIIT)combined with metformin on blood glucose in elderly patients with type 2 diabetes mellitus(T2DM).Methods Elderly T2DM patients hospitalized in Department of Endocrinology and Metabolism of First Affiliated Hospital of Air Force Military Medical University from March 2021 to March 2023 were selected and randomly divided into observation group(n=46)and control group(n=46).The con-trol group received oral metformin and meditation.The observation group took oral metformin and MIIT,and trained once ev-ery other day.Both groups were treated for 1 week.The peripheral blood glucose level during MIIT,peripheral blood glucose level before meals and before bed after the first MIIT,and maximal peripheral blood glucose level after the meal were compared between the two groups.Results There was an interaction between the peripheral blood glucose time and grouping during MI-IT(P＜0.001).At 10,30,50 min after MIIT,the levels of the peripheral blood glucose of the observation group was lower than those of the control group(P＜0.001).Compared with the same group before MIIT,the levels of the peripheral blood glucose of both groups was lower at 10,30,50,70,90 min after MIIT(P＜0.05).After the first MIIT,there was no interac-tion between pre-meal and bedtime peripheral blood glucose grouping and time(P＞0.05).There was a statistically significant difference in the main effect of grouping on the peripheral blood glucose level,and the level of the peripheral blood glucose of the observation group was 2.31 mmol/L lower than that of the control group(P＜0.001).There was no statistically significant difference(P＞0.05)in the main effect of time factors on the levels of the peripheral blood glucose before meals and before bed.There was an interaction between the maximal postprandial peripheral blood glucose grouping and time(P＜0.05).Com-pared with the control group,the maximal postprandial peripheral blood glucose level in the observation group was lower on days 2-7 after MIIT(P＜0.001).Compared with the day before MIIT,the maximal postprandial peripheral blood glucose level de-creased in both groups from 1 to 7 days after MIIT(P＜0.05).Conclusion MIIT combined with metformin may be an effec-tive strategy to control blood glucose in elderly patients with T2DM.
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