Effects of EEG bispectral index-guided sevoflurane inhalation combined with intravenous anesthesia on stress response,recovery quality and cognitive function in elderly patients with femoral neck fracture
Objective To observe the effects of EEG bispectral index(BIS)-guided sevoflurane inhalation combined intravenous anesthesia on stress response,recovery quality and cognitive function in elderly patients with femoral neck fracture.Methods A retrospective analysis was conducted on the clinical data of 113 elderly patients with femoral neck fracture who un-derwent artificial femoral head replacement in People's Hospital of Jiangyou City between January 2022 and March 2024.Accord-ing to different anesthetic method,the patients were divided into control group(n=53,BIS-guided total intravenous anesthesia)and observation group(n=60,BIS-guided sevoflurane inhalation combined intravenous anesthesia).The stress response[sys-tolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),cortisol(Cor)and malonaldehyde(MDA)],recovery quality(recovery time of autonomous respiration,recovery time of directive force and awakening time),cognitive function,Visual Analogue Scale(VAS)score and complications were compared between the two groups.Results SBP,DBP and HR of both groups at immediate intubation(T1),10 min after skin incision(T2)and the end of operation(T3)were lower than those of the same group before anesthesia induction(T0)(all P＜0.05),and the observation group was significant-ly higher than that of the control group(P＜0.05).The levels of Cor and MDA immediately after surgery,24 h after surgery and 72 h after surgery of both groups were higher than those of the same group before surgery(all P＜0.05),and the observa-tion group was significantly lower than that of the control group(P＜0.05).The recovery time of autonomous respiration,re-covery time of directive force and awakening time of the observation group were shorter than those of the control group(P＜0.05).MMSE scores of the observation group at 12 h after operation were higher than those of the control group(P＜0.05).The VAS scores of the observation group at 4,6,12 and 24 h after surgery were lower than those of the control group(all P＜0.05).There was no statistically significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion BIS-guided sevoflurane inhalation combined intravenous anesthesia can alleviate intraoperative stress reactions,improve recovery quality,improve postoperative cognitive function,and alleviate postoperative pain in elderly patients undergo-ing femoral neck fracture surgery.It has certain clinical application value.
elderlyfemoral neck fractureEEG bispectral indexsevofluraneintravenous anesthesiastress reactionrecovery qualitycognitive function
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