首页|多学科协作在老年肺癌患者化疗致周围神经毒性干预方案中的应用研究

多学科协作在老年肺癌患者化疗致周围神经毒性干预方案中的应用研究

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目的 通过分析多学科协作干预模式对老年肺癌化疗患者CIPN的效果影响,以期为临床患者的诊疗提供新思路.方法 回顾性分析2023年1月-2024年6月在南通市肿瘤医院接受化疗的84例老年肺癌患者的临床资料,依据患者不同的干预方法分为观察组(n=42)和对照组(n=42).对照组患者行化疗期间常规干预,观察组在对照组基础上应用多学科协作的干预模式.采用化疗诱导的周围神经病变评估工具(CIPNAT)评估患者CIPN症状情况、采用CIPN生活质量问卷20(EORTC QLQ-CIPN 20)量表评估患者生活质量情况.结果 干预前,2组CIPNAT量表症状体验、日常生活以及量表总分差异均无统计学意义(P>0.05);干预后,2组CIPNAT量表症状体验、日常生活以及量表总分均低于同组干预前,且观察组上述评分低于对照组(P<0.05).观察组患者CIPN分级0级、1级比例高于对照组,2级、3级和总发生率低于对照组,差异均有统计学意义(P<0.05).干预前,2组患者EORTC QLQ-CIPN 20量表评分差异均无统计学意义(P>0.05);干预后,2组患者EORTC QLQ-CIPN 20量表评分低于同组干预前,且观察组上述评分低于对照组(P<0.05).结论 多学科协作干预模式可降低老年肺癌化疗患者CIPN发生率,缓解CIPN症状,提高患者生活质量.
Application of multidisciplinary collaboration in intervention plan for chemotherapy-induced peripheral neuropathy in elderly patients with lung cancer
Objective To analyze the effects of multidisciplinary collaborative intervention mode on chemotherapy-in-duced peripheral neuropathy(CIPN)in elderly lung cancer patients undergoing chemotherapy,and provide new ideas for clinical diagnosis and treatment.Methods A retrospective analysis was conducted on the clinical data of 84 elderly lung cancer patients who underwent chemotherapy in Cancer Hospital of Nantong City from January 2023 to June 2024.They were divided into control group(42 cases)and observation group(42 cases)based on different intervention methods.The control group received routine intervention during chemotherapy,while the observation group applied a multidisciplinary collaborative intervention mode on the basis of the control group.The Chemotherapy-Induced Peripheral Neuropathy Assessment Tool(CIPNAT)was used to assess the CIPN symptoms of patients,and the CIPN Quality of Life Questionnaire 20(EORTC QLQ-CIPN 20)scale was used to evaluate their quality of life.Results Before intervention,there were no statistically significant differences in the scores of the symptom experience,daily life,and total score of the CIPNAT scale between the two groups(P>0.05).After intervention,the scores of the symptom experience,daily life,and total score of the CIPNAT scale in both groups were lower than those in the same group before intervention,and the scores in the observation group were lower than those in the control group(P<0.05).The propor-tion of patients with CIPN grade 0 and 1 in the observation group was higher than that in the control group,while the proportion of patients with CIPN grade 2,3,and the total incidence of CIPN were lower than those in the control group(P<0.05).Before intervention,there were no statistically significant differences in the scores of the EORTC QLQ-CIPN 20 scale between the two groups(P>0.05).After intervention,the scores of the EORTC QLQ-CIPN 20 scale in both groups were lower than those in the same group before intervention,and the score in the observation group was lower than that in the control group(P<0.05).Conclusion The multidisciplinary collaborative intervention mode can reduce the incidence of CIPN in elderly lung cancer patients undergoing chemotherapy,alleviate CIPN symptoms,and improve their quality of life.

elderlylung cancerchemotherapy-induced peripheral neuropathymultidisciplinary collaborationquality of lifesymptom grade

吴建霞、陈君红

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南通市肿瘤医院肿瘤内科呼吸科,江苏南通 226006

南通市肿瘤医院肿瘤内科乳腺病区,江苏南通 226006

老年 肺癌 化疗致周围神经毒性 多学科协作 生活质量 症状分级

2024

老年医学与保健
复旦大学附属华东医院

老年医学与保健

CSTPCD
影响因子:0.655
ISSN:1008-8296
年,卷(期):2024.30(6)