A clinical study on Shenyi capsule combined with immunotherapy and chemotherapy in treatment of elderly patients with ad-vanced non-small cell lung cancer
Objective To evaluate the therapeutic effects of Shenyi capsule combined with immunotherapy on patients with advanced non-small cell lung cancer(NSCLC),explore preliminarily the mechanism of action of Shenyi capsule based on the changes of cytokines,T lymphocyte subsets and immunosuppressive cells in peripheral blood of patients with advanced NSCLC,and provide new strategies for improving the overall efficacy of advanced NSCLC.Methods 60 elderly patients with advanced NSCLC admitted to Department of Medical Oncology,Traditional Chinese Medicine Hospital of Suzhou City from December 2021 to January 2024 were randomly divided into observation group and control group,with 30 patients in each group.The observation group was given Shenyi Capsule+immune checkpoint inhibitor+chemotherapy regimen,while the control group was given immune checkpoint inhibitor+chemotherapy regimen.After 12 weeks of treatment,the clinical effica-cy of the two groups was compared and statistically analyzed.Results After treatment,the levels of CD3+,CD4+,and CD8+in the observation group increased by(10.68±2.14)％,(11.69±2.32)％,and(7.96±1.83)％,respectively,which were significantly higher than those in the control group(P＜0.05).Additionally,the CD4+/CD8+ratio in the obser-vation group was significantly higher than that in the control group[(1.3 8±0.23)vs(0.95±0.17),P＜0.05)].The level of IL-6 in the observation group was significantly lower than that in the control group[(23.17±4.26)μg/mL vs(33.18±5.37)μg/mL,P＜0.05].The reduction in the levels of CRP and TNF-α in the observation group was greater than that in the control group,(P＜0.05).The weight improvement rate in the observation group was significantly higher than that in the con-trol group(83.3％vs 50.0％,P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).The toxicity reactions such as bone marrow suppression and gastrointestinal discomfort in the ob-servation group were relatively mild(P＜0.05).Conclusion Shenyi capsule can enhance the efficacy of immunotherapy in patients with advanced NSCLC and reduce adverse effects such as bone marrow suppression and gastrointestinal discomfort.
万方数据
维普
