Objective To explore the potential of serum biomarkers including GDF15 in risk assessment of dysphagia in elderly patients with cognitive impairment.Methods A retrospective analysis was conducted on data from 83 elderly patients with cognitive impairment admitted to Huai'an First People's Hospital between August 2023 and March 2024.They were divid-ed into two groups based on the presence or absence of dysphagia:the cognitive impairment group(group A)and the cognitive impairment complicated with dysphagia group(group B).The differences in general characteristics,blood biochemical indica-tors and serum biomarker level were compared between the two groups.The Kubota Drinking Test was used to evaluate swallo-wing function.Serum GDF15 level were detected by ELISA.ROC curve was used to analyze the predictive ability of the bio-markers(GDF15,IL6,PAB and ALB)for dysphagia.Results Compared with the group A,the group B was significantly older,had more severe tooth defects,and had a significantly higher rate of hyperlipidemia,suggesting that these factors may in-crease the risk of dysphagia in patients with cognitive impairment.Serum biomarker analysis showed that the levels of GDF15,IL6 and CRP in the group B were significantly higher,while the levels of PAB and ALB were lower,indicating that inflamma-tory response and malnutrition might play an important role in the occurrence of dysphagia.ROC curve analysis further con-firmed the predictive effectiveness of GDF15(AUC=0.808)and PAB(AUC=0.828)for dysphagia.The constructed logis-tic regression model based on GDF15,IL6,PAB,and ALB had an AUC value of 0.909,demonstrating high predictive per-formance and suggesting that the combined use of multiple biomarkers could provide a more accurate risk assessment for dys-phagia.Conclusion Serum GDF15 and PAB may be effective biomarkers for predicting dysphagia in elderly patients with cog-nitive impairment.The combined prediction model based on the above four biomarkers has a high predictive accuracy.
维普
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