Relationship between aspirin and Parkinson's disease:A prospective longitudinal follow-up study in a community
Objective To investigate the relationship between aspirin and Parkinson's disease(PD),as well as the role of LRRK2 gene in it.Methods This study was a prospective community-based research.Based on a follow-up cohort of nor-mal elderly population(≥ 60 years old)from a community in Shanghai from 2009 to 2011,the use of aspirin drugs among them was obtained through a questionnaire.Between 2020 and 2021,the LRRK2-G2385R genotypes of this population were se-quenced.A control population was matched according to 1∶1 propensity score matching(PSM)method.A cohort of people at high risk for PD with the LRRK2-G2385R susceptibility locus(high prevalence in Asian populations)was established.This co-hort was followed up for new cases of PD in 2020-2021.COX regression analysis was performed,and stratified analysis was conducted based on age(75 years old)and gene(LRRK2-G2385R).Results A total of 267 LRRK2-G2385R carriers and 276 controls were included,including 40 new cases of PD.After balancing the confounding factors,Cox regression analysis found that aspirin had no significant effect on the onset of PD[(HR(95％CI)=1.979(0.949-4.126),P＞0.05].After stratified by age,it was found that aspirin significantly increased the risk of PD in the population aged ≤ 75 years[HR(95％CI)=3.505(1.406～8.735),P=0.007],and sensitivity analysis reconfirmed this positive result[HR(95％CI)=2.861(1.042～7.853),P=0.041].According to the LRRK2-G2385R gene stratification,no effect of aspirin on the onset of PD was found.Conclusion According to this prospective study results of the 10-year follow-up population,it is found that the early use of aspirin is not significantly correlated with the onset of PD in LRRK2-G2385R carriers,but it may increase the risk of the onset of PD in people ≤75 years.
万方数据
维普
