Research on association between chronic obstructive pulmonary disease and diabetes mellitus in elderly patients based on data-base of National Health and Nutrition Examination Survey
Objective To explore the association between chronic obstructive pulmonary disease(COPD)and diabetes mellitus(DM)in elderly patients.Methods 5 000 subjects aged 60 years or older were selected from the database of the Na-tional Health and Nutrition Examination Survey in the United States from 2013 to 2018,and they were divided into two groups:COPD group(n=422)and non-COPD group(n=4 578).The gender,race,education level,body mass index(BMI),smoking,alcohol abuse,hypertension,DM,systolic blood pressure(SBP),diastolic blood pressure(DBP),aspartate amin-otransferase,alanine aminotransferase(ALT),serum creatinine(Scr),glycosylated hemoglobin(HbA1c),serum uric acid(UA)and total cholesterol(TC)were compared between the two groups.Multivariate Logistic regression was used to deter-mine the association between COPD and DM.Multivariate regression was used for subgroup analysis.Results Compared with the non-COPD group,the COPD group had higher rates of male,smokers,alcoholics,hypertension and DM;the levels of the education,SBP,DBP,ALT and TC of the COPD group were lower,and the levels of Scr and UA were higher.There was a statistically significant difference in the racial composition ratio between the two groups(P＜0.05).Model 1 without any co va-riate adjustment showed a negative correlation between COPD and DM(β=-0.748,95％CI:-1.008--0.488,P＜0.001).After adjusting for gender and race,Model 2 showed a negative correlation between COPD and DM(β=-0.395,95％CI:-0.680--0.110,P=0.007).After further adjusting for gender,race,education level,BMI,SBP,DBP,Scr,HbA1c,UA,TC and hypertension,Model 3 showed a positive correlation between COPD and DM(β=0.102,95％CI:-0.026-0.230,P=0.119).Subgroup analysis showed that the positive correlation between COPD and DM had an interactive effect in the racial subgroup(P for interaction=0.003).Conclusion After controlling for confounding factors,COPD is pos-itively correlated with DM to some extent,but this positive correlation varies among different races.
万方数据
维普
