Correlation of peripheral blood B/A ratio,RDW-CV and FIB with disease severity and clinical outcome in elderly patients with acute non-varicose upper gastrointestinal bleeding
Objective To analyze the correlation of the ratio of peripheral blood urea nitrogen/albumin(B/A),coeffi-cient of variation of red blood cell distribution width(RDW-CV)and fibrinogen(FIB)with disease severity and clinical out-come in elderly patients with acute non-varicose upper gastrointestinal bleeding(ANVUGIB).Methods 129 elderly patients with ANVUGIB admitted to Third People's Hospital of Chengdu City from May 2022 to May 2024 were included in the study.According to scores of Glasgow-Blatchford Scoring System(GBS),they were divided into low-risk group(n=77,GBS score ≤6 points)and medium-high risk group(n=52,GBS score＞6 points).The levels of B/A,RDW-CV and FIB were compared between the two groups.The correlation between the levels of B/A,RDW-CV and FIB and disease severity was ana-lyzed by Spearman analysis.According to clinical outcome,patients were divided into improvement group(n=88)and death group(n=41).The predictive value of B/A,RDW-CV and FIB for clinical outcomes was analyzed by receiver operating characteristic(ROC)curves.Results B/A and RDW-CV in the low-risk group were lower than those in the medium-high risk group,while FIB was higher than that in the medium-high risk group(P＜0.05).Spearman analysis showed that B/A and RDW-CV were positively correlated with disease severity,while FIB was negatively correlated with disease severity(r=0.769,0.772,-0.689,P＜0.05).B/A and RDW-CV in the improvement group were lower than those in the death group,while FIB was higher than that in the death group(P＜0.05).ROC curves analysis showed that area under the curve(AUC),sensitivity and specificity of serum B/A,RDW-CV and FIB for predicting clinical outcomes were(0.823,0.831,0.818),(80.49％,68.29％,70.73％)and(78.41％,88.64％,77.27％),respectively(P＜0.05).Conclusion The levels of serum B/A,RDW-CV and FIB are significantly correlated with diseases severity in elderly patients with ANVUGIB.They have high predictive value for clinical outcomes and may provide a reference for clinical treatment and have certain clinical reference value.
elderlyacute non-variceal upper gastrointestinal bleedingratio of blood urea nitrogen/albumincoefficient of variation of red blood cell distribution widthfibrinogen
万方数据
维普
