Objective To investigate the efficacy of CT signs combined with texture features for the differential diagno-sis between focal autoimmune pancreatitis and pancreatic cancer.Methods We retrospectively collected and collated the diagnostic CT images between 50 patients with focal autoimmune pancreatitis(f-AIP)and 50 patients with pancreatic cancer(PC)that had been clinically or pathologically confirmed by biopsy,performed a comparative analysis of the status of the CT morphological signs of the two diseases,compared the intergroup differences between the two groups,and established a diag-nostic model of the CT signs,texture features,and the combined texture features of the CT signs.ROC curve analysis was ap-plied to the model results.Results In this study,50 patients with f-aip will receive pathological confirmation or clinical confirmation by biopsy,while 50 patients with PC will receive pathological confirmation by biopsy.the diagnostic yield of CT findings suggested that the pseudocapsule sign and pancreatic duct traversal pattern were more frequent in the f-aip patients than in the PC patients,whereas peripancreatic cord and vessel involvement were more frequent in the PC patients with P＜0.05;there were no statistical differences in lesion location,atrophy of the distal uninvolved tissue,annular thickening of the common bile duct wall,dilation of the upstream bile duct and lymphadenopathy between f-aip and PC(P＞0.05);the AUC values for the CT sign model,the texture feature model,and the combined model were 0.854,0.882,and 0.914;The sensi-tivity and specificity of the combined diagnostic model in clinical diagnosis were higher than those of the two previous diag-nostic models.Conclusion In order to identify focal autoimmune pancreatitis and pancreatic cancer,CT sign combined with texture feature diagnostic analysis can be applied in clinical diagnosis,and the application value of the combined diag-nostic model is higher than that of single diagnostic technique.
维普
万方数据