Correlation of Peripheral Blood miR-23b-3p and miR-223 Levels with the Clinical Outcomes and Prognosis of Children with Severe Pneumonia Underwent Fiberoptic Bronchoalveolar Lavage
Correlation of Peripheral Blood miR-23b-3p and miR-223 Levels with the Clinical Outcomes and Prognosis of Children with Severe Pneumonia Underwent Fiberoptic Bronchoalveolar Lavage
Objective To investigate the correlation of peripheral blood miR-23b-3p and miR-223 levels with the clini-cal outcomes and prognosis of patients with severe pneumonia underwent fiberoptic bronchoalveolar lavage.Methods Eighty children with severe pneumonia and another 80 children with common pneumonia underwent fiberoptic bronchoalveo-lar lavage in our hospital from January 2019 to January 2020 were enrolled,and set as case group and control group,respec-tively.Levels of peripheral blood miR-23b-3p and miR-223 were detected,and compared between the two groups.Then the correlation of peripheral blood miR-23b-3p and miR-223 levels with the prognosis of children with severe pneumonia was discussed.Results The level of peripheral blood miR-23b-3p in case group was lower than that of control group(P＜0.05),and the level of peripheral blood miR-223 was higher than that of control group(P＜0.05).The peripheral blood miR-23b-3p level of good prognosis group was higher than that of poor prognosis group(P＜0.05),and the miR-223 level was lower than that of poor prognosis group(P＜0.05).The level of peripheral blood miR-23b-3p was positively correlated with the clinical effect and prognosis of children with severe pneumonia(P＜0.05),and the level of peripheral blood miR-223 was negatively correlated with the clinical effect and prognosis of children with severe pneumonia(P＜0.05).Conclu-sion Peripheral blood miR-23b-3p and miR-223 expression levels affect the efficacy and prognosis of children with severe pneumonia underwent fiberoptic bronchoalveolar lavage,in which peripheral blood miR-23b-3p has an inhibitory effect on inflammation,while miR-223 is pro-inflammatory,so the preoperative detection of both indicators is of great clinical signifi-cance.
维普
万方数据