摘要
目的 探究肿瘤切除术后肝动脉介入化疗栓塞术对原发性肝癌患者生存率及复发情况的影响.方法 选安阳市肿瘤医院2019年1月至2020年5月期间92例原发性肝癌患者为研究对象,将其随机分为A组、B组,各46例,分别实施肝脏肿瘤切除术、肝脏肿瘤切除术联合肝动脉介入化疗栓塞术治疗,比较两组术前、术后3个月时肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)]、肿瘤血清标志物[甲胎蛋白(AFP)、AFP-L3、糖类抗原(CA)199、磷脂酰肌醇蛋白聚糖-3(GPC3)]及术后1年、2年生存率、复发率.结果 术前B组AST、ALT、TBIL水平与A组相近(P＞0.05);术后3个月B组AST、ALT、TBIL水平较A组低(P＜0.05);术前B组AFP、AFP-L3、CA199、GPC3 水平与 A 组相近(P＞0.05);术后 3 个月 B 组 AFP、AFP-L3、CA199、GPC3 水平较 A 组低(P＜0.05);术后1年、2年B组生存率分别为91.30％、82.61％,均较A组73.91％、63.04％高(P＜0.05);术后1年、2年B组复发率分别为8.70％、13.04％,均较A组26.09％、34.78％低(P＜0.05).结论 在原发性肝癌患者肿瘤切除术治疗基础上,联合肝动脉介入化疗栓塞术治疗,可改善其肝功能,降低肿瘤血清标志物水平,提升生存率,降低复发率,效果显著.
Abstract
Objective To investigate the effect of transcatheter arterial chemoembolization(TACE)on the survival rate and recurrence of patients with primary liver cancer after tumor resection.Methods 92 patients with primary liver cancer in Anyang Cancer Hospital from January 2019 to May 2020 were selected as the research object,and they were randomly di-vided into group A and group B,with 46 patients in each group.They were treated with liver tumor resection,liver tumor re-section combined with hepatic artery interventional chemotherapy and embolization,respectively.The liver function indexes[AST,ALT,TBIL]Serum tumor markers[alpha fetoprotein(AFP),AFP-L3,carbohydrate antigen(CA)199,phosphatidyli-nositol proteoglycan-3(GPC3)],1-and 2-year survival rates and recurrence rates after surgery.Results The levels of AST,ALT and TBIL in group B were similar to those in group A before operation(P＞0.05);The levels of AST,ALT and TBIL in group B were lower than those in group A 3 months after operation(P＜0.05);The levels of AFP,AFP-L3,CA199 and GPC3 in group B were similar to those in group A before operation(P＞0.05);The levels of AFP,AFP-L3,CA199 and GPC3 in group B were lower than those in group A 3 months after operation(P＜0.05);The 1-year and 2-year survival rates of group B were 91.30％and 82.61％respectively,which were higher than 73.91％and 63.04％of group A(P＜0.05);The recurrence rates of group B were 8.70％and 13.04％at 1 and 2 years after operation,respectively,which were lower than 26.09％and 34.78％of group A(P＜0.05).Conclusion On the basis of tumor resection for patients with primary liver cancer,combined with transcatheter arterial chemoembolization can improve their liver function,reduce the lev-el of tumor serum markers,enhance survival rate and reduce the recurrence rate.
维普
万方数据